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Clinical assessments were conducted every 3 months to evaluate efficacy, measured as percentage of total weight loss (%TWL), excess weight loss (%EWL), changes in BMI, and improvement in comorbidities, as well as tolerance, monitored for adverse effects including gastrointestinal symptoms (e.g., nausea, vomiting, diarrhea) and discontinuation rates

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These include over-the-counter creams that contain capsaicin or salicylates, or a 1% diclofenac gel (Voltaren)

In off-label discussions, commonly referenced ranges include: Semaglutide: approximately 0.050.125 mg weekly Tirzepatide: below 1 mg weekly For a closer look at typical low-dose ranges, see our tirzepatide microdosing chart

Based on current clinical evidence, Mounjaro (tirzepatide) is generally the best tolerated of the available options, with lower rates of nausea compared to semaglutide at equivalent weight loss doses