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Cardiometabolic Improvements Weight loss was accompanied by clinically meaningful improvements across several cardiovascular risk markers, including reductions in: Waist circumference (mean reduction of approximately 24.1 cm at the highest dose) Non-HDL cholesterol Triglycerides Systolic blood pressure High-sensitivity C-reactive protein (hsCRP) a marker of inflammation These findings are particularly relevant for patients with obesity who also live with cardiometabolic conditions, where systemic risk reduction is as important as the weight loss itself

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(2019) 8: doi: 10.5812/jjcdc.90213 66

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Second, the glucagon receptor component of retatrutides mechanism appears to have direct anti-inflammatory effects beyond what weight loss alone produces