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measured MMP1, MMP2, TIMP1, and TIMP2 gene expression in human adult dermal fibroblasts exposed to GHK-Cu at 0.01, 1, and 100 nanomolar concentrations and found dose-dependent increases in both MMPs and their inhibitors 11

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LPS stimulation for 4 h caused the translocation of NF-B p65 to the nucleus in RAW 264.7 cells (Figure 3B)

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