Without a companion program, its possible to end up with sarcopenic obesity and a higher body fat composition than before starting the meds up to 40% of weight loss can be muscle
(7) New GLP-1 Therapies Enhance Quality of Weight Loss by Improving Muscle Preservation. American Diabetes Association, 2025
In this pathway, adipocytes secrete leptin, which transmits energy storage signals to the hypothalamus
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Neuropharmacology 149 , 124132 (2019)