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The development of melanocytes from neural crest cells, as well as their ability to migrate, is dependent upon interactions between specific receptors and extracellular ligands, including endothelin 3 and the endothelin B receptors, melanocyte stimulating hormone and the melanocortin-1 receptor stem cell factor and its receptor KIT, each of which induce expression of the microphthalmia-associated transcription factor (MITF)

If you're concerned about a possible side effect, you can report it via the MHRA Yellow Card Scheme (yellowcard.mhra.gov.uk or the Yellow Card app)

67 Nevertheless, uric acid has a highly reducing structure that effectively neutralizes free radicals and mitigates their harmful effects

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For electrophysiology and immunohistochemistry experiments, Pomc -humanized Renilla reniformis green fluorescent protein (hrGFP) mice (#006421, Jackson Laboratory, Bar Harbor, ME, USA) were utilized