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While higher doses (e.g., 20mg) are studied for maximal weight loss, the 10mg formulation provides an ideal concentration for dose-response analysis, receptor saturation studies, and mechanistic investigations into the contribution of each receptor subtype

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Distribution High plasma-proteinbinding Widely distributed through the body, including: Bloodbrain barrier BloodBrain Barrier Meningitis in Children Placenta Placenta A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products

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