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As a thiol-containing compound, NAC is readily oxidized to disulfide dimer Di-NAC [60]Hamlow EE, Peck GE

First, it is plausible that DPI penetration to the sites of lucigenin action may be limited in intact cells (this would explain why DPI was so much more effective in suppressing the lucigenin chemiluminescence observed in cell-free partially purified CYB5R preparations, compared with transiently transfected intact cells [35]) or alternatively, a second DPI-insensitive enzyme system may exist in whole cells, that is also capable of activating lucigenin

Discussion The RNA helicase DDX3X has primarily been associated with cellular RNA metabolism, the interferon response and modulation of RNA viruses