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SNAC was originally developed by Emisphere, and has been granted GRAS (generally recognized as safe) status by the FDA for use with food supplements, vitamins and dietary ingredients (256)

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In one example of a physiological response to osmotic pressure, in early mammary gland milk production osmoregulatory pathways are exploited using asymmetric kinetics to increase the carnitine concentration in milk for suckling neonates who have reduced carnitine stores, even though this results in decreased maternal liver stores [20]