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Las zonas afectadas con ms frecuencia son las reas expuestas (dorso de manos, cara) y en regiones que presentan de manera fisiolgica una mayor pigmentacin (pliegues palmares, areolas, genitales externos, ano), adems de cicatrices y mucosa oral

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Thus, developing effective treatment and preventive strategies in melasma is a work in progress that depends on a better understanding of its pathogenesis