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At least 35 different mutations in the HLCS gene have been found associated with holocarboxylase synthetase deficiency

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While structural differences may exist for larger, higher-acuity hospitals (such as VHA hospitals and academic medical centers) that could make improved Safety of Care performance more difficult to achieve, we note that these hospitals do tend to both have more Safety of Care measures available and larger volumes for the measures they do have, both factors that increase measure reliability and reduce the possibility of score reductions based on chance variation

doi: 10.1111/gcb.16209 71 SchirrmacherP.RoggatzC