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Since the isolation of the cDNA in 1994, the work on the mammalian Molecular Biology of Methylenetetrahydrofolate Reductase (MTHFR) and Overview of Mutations/Polymorphisms MTHFR gene has resulted in significant advances in our understanding of its genomic organization, genetic variations and involvement in human disorders

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Publicly available TCGA data were accessed and analyzed using the GEPIA2 web at All other data generated in this study are available within the Article, Supplementary Information, or Source Data