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Tablets were compressed to a hardness ranging from 3-10 Kp for 1/4 inch diameter tablets weighing 200 mg and 6-16 Kp for 5/16-13/32 inch diameter tablets weighing 200-400 mg

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WAT is distributed throughout the body, being mainly classified as subcutaneous (sWAT) and visceral (vWAT), but also including inter-/intramuscular and bone marrow depots [38]

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Izokibep, a small IL-17Atargeting protein, may improve tunnel penetration and is currently in phase 3 trials following favorable phase 2b results in antiTNF-refractory moderate-to-severe HS [NCT05905783 [242];]