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All assays were performed strictly following the manufacturers instructions

For de novo NADPH synthesis pathway, correlation studies have revealed that thionicotinamide adenine dinucleotide (NADS) and thionicotinamide adenine dinucleotide phosphate (NADPS), converted from the pro-drug thionicotinamide (TN), act as inhibitors of NADKs through targeting the NAD-binding site of NADKs and decreasing the levels of NADPH

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demonstrated on-resin peptide macrocyclization via thiol-ene reaction between Cys and terminal alkene bearing side chains of four to six carbons in length (Zhao et al., 2016)

Vitamin B6, vitamin B12 and methionine and risk of pancreatic cancer: a meta-analysis