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Receptor radioligand competition binding The binding properties of mAb 3F52 and Fab 3F52, respectively, were tested by Scintillation Proximity Assay (SPA)(Perkin Elmer) on membranes of BHK cells stably over-expressing human, cynomolgus, rat, mouse and pig GLP-1 receptors
Endothelial cell dysfunction is a critical early event in the pathogenesis of cardiovascular diseases, including atherosclerosis, and is strongly driven by oxidative stress [1] [2] [3]
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For young patients with mild disease not desiring children, it is advisable to use medical suppression to control symptoms and minimize surgical interventions
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