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Additionally, stress-inducing agents such as tunicamycin, thapsigargin and histidinol have been shown to modulate CHAC1 regulation, indicating its involvement not only during ER stress but also in the context of the ISR ( CHAC1 promoter is the primary mechanism for the transcriptional upregulation of the gene

Naringenin, an abundant flavanone in citrus fruits (Kaulaskar et al., 2012) and genistein, a natural phytoestrogen from soybean (Valsecchi et al., 2008), have been exhibited analgesic, antioxidant and immunoregulatory properties in sciatic nerve injury models