This aligns with findings in sepsis models, where glycocalyx damage exacerbates vascular permeability and leukocyte adhesion [10, 24]
(See What to Consider When Buying) L-citrulline safety and side effects: L-citrulline supplementation appears to be generally safe and well tolerated in healthy individuals, although occasionally, gastrointestinal upset and heartburn have been reported, and it should be used with caution by people on medication that lowers blood pressure
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[46] While higher protein meals do increase TEF, this is only a short-term increase in energy use and there is little evidence that this mechanism reliably produces an increase in total daily energy expenditure, and, if so, improves weight loss outcomes or prevents the development of obesity