does glp 1 cause bone loss GLP-1 and Health: Beyond Weight in the Ozempic Era Effects of incretin-based therapies on

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Key factors that may influence bone health during GLP-1 treatment include: Rate and magnitude of weight loss : Losing weight rapidly or losing a substantial percentage of body weight may reduce mechanical stress on bones, potentially leading to decreased bone mineral density

Against this backdrop of rising obesity and new pharmacologic strategies, it is critical to note that the majority of patients undergoing orthopedic surgery, particularly joint arthroplasty, meet criteria for obesity (BMI 3039.9) or morbid obesity (BMI 40)

30 Keliher et al ran a series of modifications of Lys 12 in exenatide, indicating that this position is not important for interactions with GLP-1R and that it is, to some extent, tolerant of bigger groups

doi: 10.1208/s12248-015-9854-1 86 SatoKKamedaMYasuharaTAgariTBabaTWangFet al