Avoid alcohol during treatment, and keep in mind that Topamax can make hormonal birth control less effective at doses greater than 200 milligrams (mg) per day
Because it shares pharmacological features with licensed GLP-1 receptor agonists such as semaglutide and tirzepatide, clinically relevant interactions including with antidiabetic medicines, anticoagulants, and narrow therapeutic index drugs can be anticipated
Clinical trials are also looking into whether the drug has benefits for knee osteoarthritis pain, moderate-to-severe obstructive sleep apnea, and chronic low back pain, Rhodes says
Metabolic Adaptation and Plateau Phases Weight loss plateaus are a normal physiological response, not a medication failure
Eating a nutrient-poor, protein-poor diet will not do much to help sustain lean body mass