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Synthetic formulations mimic this effect in tissues throughout the body

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While all treatments slightly affected the Johnsen score in controldiet animals, antioxidant therapy alone fully restored the AGEinduced decrease to control levels, whereas ALT711 alone produced only a partial rescue

Possible mechanisms for the increased ADMA concentrations include the involvement of the methionine-homocysteine pathway in the biosynthesis of ADMA and the homocysteine-mediated inhibition of ADMA metabolism by the enzyme DDAH [21], [22]