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Prior research indicated that I NaP currents contribute to burst firing and resonance by facilitating subthreshold oscillations, thereby enabling rhythmic activity (Wu et al., 2005

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In TRIUMPH-1, discontinuation rates due to adverse events were 4.1% on 4 mg, 6.9% on 9 mg, and 11.3% on 12 mg, compared with 4.9% on placebo