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Approaches include redox interactions with high-valent metal ions (like Cu 2 and Fe 3 ), suppression of GSH synthesis using agents such as BSO, the use of nanozymes that mimic enzymatic activity, and direct GSH neutralization through molecular binding [18]

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Furthermore, when glutathione levels are insufficient, free radicals begin to attack the lipid bilayers that form the outer membranes of all human cells, a process known as lipid peroxidation