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Some animal studies have even shown hormonal changes and ovarian stress after long-term use

Indeed, glomerular podocytes and tubular epithelial cells require a bundle of mitochondria to provide sufficient energy to remove waste from the blood and maintain the electrolyte balance (90)

An RCT in 72 patients with NAFLD found that NAC (600 mg twice daily) for 3 months significantly improved liver enzymes (ALT, AST) and markers of oxidative stress compared to control, though it did not significantly improve liver histology on biopsy (Khoshbaten et al., Hepat Mon, 2010) [33]