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(B) Body weight of the two groups (Ctrl, n = 6

However, a possible obstacle to this therapy is ghrelins half-life

Tryptophan oxidation is the degradation route most commonly detected by RP-HPLC in stored melanocortin analogues, with histidine a secondary site of concern, and freeze-thaw cycling accelerates both aggregation and oxidative degradation

Besides, the elevated ratio of free to conjugated BA (CA/GCA + TCA) denoted the enhanced activity of bile salt hydrolase (BSH) (Juarez-Fernandez et al., 2021), which promoted the deconjugation of conjugated BA and conversion to free BA