Safety Considerations and Contraindications GHK-Cu is generally well-tolerated in topical form, but caution is warranted in patients with certain sensitivities or systemic conditions
Extra caution and monitoring make sense here
Hormone level fluctuations: There is a view that creatine may affect the secretion of androgen, leading to problems such as facial acne, but whether the external application form will cause such side effects still needs further research
ISBN: 978-0-323-08691-2 Kowalkowski K, Klapczynski M, Blomme E, Buck W, Liguori M (2017) Evaluating in vitro canine kidney slices as a renal toxicity model using nephrotoxic agents cisplatin and cadmium chloride
It appears to affect multiple neurotransmitter systems and has been shown to influence serotonin, dopamine, and GABA systems