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To understand the upstream signalling pathways that may be driving gene expression changes in HFpEF hepatocytes with semaglutide treatment, we performed HOMER motif analysis on the genes differentially up- and down-regulated compared to hepatocytes from vehicle-treated samples

These findings suggest that GLP-1R signaling remains functional in Bbs5 / mice and could represent a promising therapeutic target for the hyperphagia and obesity associated with BBS

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In a clinical trial with 2,519 patients, Zepbound (tirzepatide) was taken at doses of 5 mg, 10 mg, and 15 mg over a 72-week period, with an additional 958 people receiving a placebo