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Difficult timing: John explains that oral semaglutide must be taken on an empty stomach and requires a 30-minute wait before eating, which can be hard to maintain long-term

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[3] The 1998 UKPDS 34 trial (N=1,704 overweight patients with newly diagnosed type 2 diabetes) published in The Lancet demonstrated that intensive metformin therapy reduced all-cause mortality by 36% and diabetes-related endpoints by 32% compared with diet alone, evidence that forms the clinical backbone of every coverage defense for this drug