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A recent pooled analysis of the LEADER and SUSTAIN-6 studies demonstrated a lower risk for persistent 40% or 50% reduction in eGFR from baseline [32]

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Thereafter, the patient will come in once monthly for a follow up exam and to renew their prescription

[363] The numerator thresholds were developed according to evidence and consensus-based clinical guidelines for ED time thresholds from a TEP and environmental scans