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10.1056/NEJMoa2413258 123 SargeantJ

When the body perceives significant energy deficit or metabolic stress, it may suppress reproductive function as a protective mechanism

The cystic fibrosis transmembrane conductance regulator (CFTR) in the endometrial epithelial cells transports chloride ions from the cytosol to the uterine lumen, which is crucial for maintaining uterine fluid homeostasis and regulating apoptotic activity of endometrial epithelial cells, all critical for embryo implantation

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Also, in elderly diabetic patients with obesity, semaglutide therapy led to a moderate but clinically relevant reduction in BW and BMI after 3 months