If you want to use it, you should ask a doctor first, especially if you're already sick or taking other medicines
One of the commonly reported microbiome differences between obese/HFD-fed animals and lean controls is an increased Firmicutes : Bacteroidetes ratio 43,44
PD-1, associated synergistic genes inserted into the HSV genome, include single, stranded variable fragment PD-1 (ScFvPD-1), variable region components of antibodies targeting programmed death receptor one (anti-PD-1 Fab),and portions acting as PD -1 blockers (PD-L1B)
"Thymosin beta4 accelerates wound healing." Journal of Investigative Dermatology , 1999
If you worry are too much about the discomfort, then a numbing agent will be applied to avoid minor pain during the injection