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Glucagon-like peptide 1 (GLP-1) is a naturally occurring hormone produced by the body that helps to regulate blood sugar levels and plays a key role in controlling the level of satiety one feels after one eats

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In addition to its effects on appetite, semaglutide slows gastric emptying, meaning food remains in the stomach for longer, which further contributes to satiety

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A landmark trial in the New England Journal of Medicine found that patients maintaining GLP-1 therapy preserved 80% of their weight loss two years into treatment, while those who stopped regained most losses