Departure Lounge Credits Miles Brown - theremin, synth, programming, electronics Sarah Lim - synth All tracks composed, performed, recorded and produced by Miles Brown Recorded at Die Hit Fabrik Berlin, Sameheads Berlin and Castle of Terror Melbourne Mixed by Tony Espie and Tufftones Melbourne Mastered by David Walker at Stepford Audio Melbourne Art and design by Luke Fraser/AHR+ Photography by Nicole Reed
PLOS Med
These effects accumulate in brain tissue and persist longer than the compound remains in the bloodstream: A single dose's effects on synaptic density, VEGF signalling, and neuroprotective cascades may last for hours or days after blood levels have dropped to zero Repeated dosing likely leads to cumulative effectseach dose "adds to" the previous dose's neurobiological changes Anecdotal reports of sustained effects after discontinuation (weeks to months in some cases) are consistent with persistent brain changes rather than active drug presence Implications for Dosing This is a crucial point: the observation that effects outlast blood concentrations explains why some community members report benefits from periodic (not daily) dosing and why cycling protocols exist
Reduced FH enzyme activity leads to the accumulation of the cellular level of fumarate, and fumarate can undergo a reaction with cysteine residues of proteins, which is called succination (Pollard et al., 2005)
I think, with diabetes, type 2 diabetes, with any intervention really, these patients lose less weight than if they just had obesity alone without diabetes
