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That single action prolongs the sense of fullness, but it is also the direct source of the characteristic gastrointestinal side effects of the GLP-1 class, from nausea to constipation
Limitations of this approach, however, include the lack of quantitative analysis and of a structured assessment of the quality of studies and certainty of evidence, which were beyond the scope of this descriptive work
Exendin-4, liraglutide and semaglutide can directly or indirectly stimulate POMC neurons in the ARC, while indirectly inhibiting NPY/AgRP neurons via presynaptic GABAergic neurons [82-84]
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