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Unlike therapies directly targeting tumour cells, the effectiveness of CAF-targeted therapies largely depends on the microenvironment and the composition of tumour stroma in patients

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Extensive, albeit fragmentary, findings from neurochemical and neuroendocrine studies of SZ ( Figure 1 ), suggesting a link among oxidative stress, membrane dysfunction, and multi-neurotransmitter pathologies in SZ ( FIGURE 1 METABOLOMIC INVESTIGATION Schizophrenia is a heterogeneous disease with various abnormal metabolites involving multiple biochemical pathways

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CRP binds and aggregates oxidized low-density lipoprotein (ox-LDL) and enhances macrophage oxLDL uptake, promoting mitogen-activated protein kinase activation (171) required for foam cell formation (172)