26 METABOLIC-BARIATRIC SURGERY Metabolic-bariatric surgery and endoscopic procedures modulate gut hormones (eg, GLP-1, peptide YY, ghrelin), improve insulin sensitivity and mitochondrial function, and reshape the gut microbiome, all of which contribute to decreasing hepatic steatosis
Imaging as a tool for understanding incretins and their effects With multiple drugs in development targeting the GLP-1, GIP, and glucagon receptors, it becomes important to understand how each peptide is engaging with the receptors and hoe this shapes the resulting pharmacological effects
NAD+ restores a critical coenzyme for energy production
Adipocytes were then treated with G49 (500 nM) for 4 h
CETP facilitates the transfer of cholesteryl esters from HDL to apolipoprotein B-containing lipoproteins, effectively lowering HDL-C and increasing LDL-C