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Weight loss ranges from 12% to 18% in a stepwise manner from single agent GLP-1 agonist to triple agonists therapy (Table 1)

Excessive release of glutamate and its binding with NMDA, -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), or kainite (KA) receptors promotes excitotoxicity cell injury with a consequent activation of many molecular pathways, resulting in intracellular calcium (Ca 2+ ) overload 90,91 , reactive oxygen species (ROS) production, mPT, and cell swelling with brain edema 92

We then divide 2/100 to get the absolute risk in the group taking the medication, which is 2%

[DOI] [PMC free article] [PubMed] [Google Scholar] 74.Napolitano G., Fasciolo G., Di Meo S., Venditti P