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Ozempic reduced the annual rate of change in eGFR 1 For adults with T2D and CKD for a confirmatory secondary endpoint: observed mean change in eGFR over time (the annual rate of change in eGFR) vs placebo when both were added to standard of care 1,2 Observed mean plot: eGFR (mL/min/1.73 m 2 ) by week in FLOW trial 1,2,ff ff Observed data from the in-trial period until Week 104

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Mohammed D, Crowther JM, Matts PJ, Hadgraft J, Lane ME