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When conventional lifestyle modifications (including caloric restriction and increased physical activity) prove insufficient for achieving clinically meaningful weight reduction, pharmacological interventions or metabolic bariatric surgery may be considered to improve quality of life and mitigate obesity-related complications

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These hormones act on multiple sites in the circadian system, modifying processes at the cellular and molecular levels

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This subsequently suppresses pyroptosis in KCs, thereby alleviating the inflammatory response in NAFLD [177]