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These issues are typically linked to indirect effects such as gastrointestinal symptoms, altered eating patterns, or nocturnal hypoglycaemia rather than a direct pharmacological action

The newer approvals marked a game changer for treating obesity and weight gain, which had been widely stigmatized and thought of primarily as a willpower issue, Harris said, when genetic or biological factors can cause some patients to gain weight more easily and have more difficulty losing weight

Monitoring electrolytes and renal function is advisable during significant weight loss or when gastrointestinal side effects are prominent