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From a therapeutic perspective, GLP-1 receptor agonists drugs that mimic the endogenous hormone GLP-1 are used to treat type 2 diabetes and obesity by improving insulin secretion, lowering blood sugar, and supporting weight reduction

In the REDEFINE 2 trial, CagriSema achieved a 15.7% weight loss in patients with type 2 diabetes over 68 weeks

Back Raufman, J-P, Tensen, RT, Sutliff, VE, et al (May 1982) 'Actions of Gila monster venom dispersed from guinea pig pancreas', American Journal of Physiology , 242/5, G470-4

While effective for glycemic control and weight reduction, these physiological changes may trigger headaches in some patients

L., Yusta, B., Mulvihill, E