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Who Should Avoid MOTS-c Pregnant or breastfeeding individuals People with an active cancer diagnosis, since MOTS-c may affect prostate and breast cancer pathways Those taking AMPK-activating medications like metformin, thiazolidinediones, or aspirin Anyone on insulin or with uncontrolled diabetes without medical supervision Minors and adolescents Athletes in tested sports, since MOTS-c is on the WADA Prohibited List under Section S4 Anyone without access to lab-verified research peptides MOTS-c vs Other Metabolic Peptides (High-Level Comparison) MOTS-c vs Semaglutide MOTS-c works through the mitochondrial pathway with gradual, muscle-preserving results

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[14] [16] Pre-treatment with IGF-1 also blunts the GH-elevating effect of examorelin

Eur J Clin Invest 24 : 733736