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NAPQI is being conjugated at the rate at which new GSH is being synthesized, which keeps the concentration of GSH from rising

Both drugs can independently cause tachycardia (increased heart rate), and together they may compound this effect, increasing the risk of arrhythmias and other cardiac events

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1 Smaller amounts of GLP-1 are also produced by neurons in the nucleus tractus solitarius (NTS) of the brainstem, thus highlighting its dual role in both peripheral and central metabolic regulation