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Open 3 , e201965 (2020)

Alnylams inclisiran, which uses RNA interference to reduce PCSK9 protein expression and thereby lower LDL cholesterol, can be dosed twice yearly versus daily oral statins or biweekly PCSK9 monoclonal antibody injections

The DEGs were significantly enriched in metabolic pathways, protein digestion and absorption, retinol metabolism, MAPK signaling pathway, PI3KAkt signaling pathway, Wnt signaling pathway, PPAR signaling pathway, and TGF-beta signaling pathway (Figure 4A)

The signals of the products were standardized against glyceraldehyde 3-phosphate dehydrogenase (GAPDH) signals of each sample