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Free radicals are unstable molecules generated by factors like UV radiation, pollution, and stress, which can damage skin cells and accelerate aging

That rate of vomiting is intense along with a super high rate of nausea and this trial used a slow titration protocol

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At week 16 of the phase III, randomized, BRIDGE study, PASI 75 was reached by more than one third of patients enrolled (8), while in the large retrospective FUTURE study it was demonstrated a mean reduction of 79% in PASI from baseline (72)