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In mice lacking Nav1.6 channels, I NaP currents are reduced by 39%, and I NaR currents are suppressed by 76%, leading to the loss of subthreshold oscillations, impedance resonance, and both spontaneous and evoked rhythmic firing (Enomoto et al., 2006, 2007)

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This means staying under approximately 20 to 30 grams of net carbohydrates per day for most people

These results highlight the role of MOTS-c in energy balance

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