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The Effect of GLP-1RAs on Epicardial Adipose Tissue GLP-1Rs are expressed in both subcutaneous and visceral adipose tissue

Skin flap necrosis and poor wound healing may also occur, especially in patients with compromised vascularity or ongoing weight fluctuations, he noted

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Some studies indicate that DSIP may influence endogenous opioid signaling, although its effects are not consistently reversed by opioid antagonists, suggesting indirect modulation rather than direct receptor agonism [9]