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however, compounded medications are not FDA-approved and do not undergo safety, effectiveness, or manufacturing review

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Sublingual drops claim higher absorption than gastric tablets because the sublingual mucosa is thin, highly vascularized, and does not expose the peptide to stomach acid

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Treatment stage What may be common What deserves attention Week 1 Nausea, fullness, reduced appetite, bloating, indigestion, diarrhea, constipation, fatigue Repeated vomiting, severe pain, inability to stay hydrated Weeks 2 to 4 Early symptoms may settle, persist, or fluctuate Symptoms interfering with eating, drinking, or daily function Weeks 5 to 8 Symptoms may reappear after clinician-directed dose escalation A significant return or worsening of gastrointestinal symptoms Months 2 to 3 Some patients tolerate treatment more comfortably

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