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In orientation 2, the HQ molecule is oriented similarly to tyrosinase substrates (and KA) in the active site, supporting our kinetic experiments showing that HQ can act as a TyrBm substrate (Fig

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The ability of GPCRs to signal from different subcellular compartments is now well-established 12,13,14,15,16,17,18,19,20,21 and there is convincing evidence that subcellular signaling can lead to ADRs 22,23,24,25