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389 GLP-1RAs and fat metabolism GLP-1RAs work via numerous mechanisms that contribute to weight loss, one of the most well-known of which is the gut-brain axis

It is a reason to slow down and reassess

Whilst oral bioavailability is relatively poor (less than 5% reaches systemic circulation due to extensive first-pass metabolism), sufficient absorption occurs to produce measurable pharmacological effects in research settings

Some side effects are known and documented

The drugs' prescribing information makes that clear too: They "should be used in combination with a reduced-calorie diet and increased physical activity." And "watch what you eat" doesn't just mean cutting back on fast food