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[3] Intramuscular injection, or more specifically peri-lesional injection near an injured tendon or joint, has been used in animal models to test whether local delivery produces superior effects compared to systemic dosing

J Exp Med 192:10011014 Kehrer JP (2000) The Haber-Weiss reaction and mechanisms of toxicity

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Concurrently, moderate levels of ROS serve as critical secondary messengers that activate key pro-survival and proliferative signaling pathways including MAPK, PI3K/AKT, NF-B, and HIF-1