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Advantages: - Once-weekly convenience for most formulas - Well-studied efficacy and safety data - More consistent absorption - Compounded versions available at lower cost Considerations: - Requires self-injection or provider administration - Needles can be a barrier for some patients Oral semaglutide (Rybelsus) is currently the only FDA-approved oral GLP-1 medication

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Pre-clinical research conducted primarily in animal models has studied its potential roles in supporting the GI environment, gut barrier function, and inflammatory responses in the GI tract

Some formulas also include ingredients like niacinamide, vitamin C, licorice extract, aloe vera, glycerin, or hyaluronic acid